Sulfur-containing spiroketals from Breynia disticha and evaluations of their anti-inflammatory effect

• Ken-ichi Nakashima,
• Naohito Abe,
• Masayoshi Oyama,
• Hiroko Murata and
• Makoto Inoue

Beilstein J. Org. Chem. 2023, 19, 1604–1614, doi:10.3762/bjoc.19.117

• effects of the isolated compounds were evaluated based on the mRNA levels of proinflammatory cytokines in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophage cells. Compounds 1, 2, 6, and 7 inhibited the increase in interleukin (IL)-1β and IL-6 mRNA levels stimulated by LPS. Moreover, the most

• compounds isolated in this study, we investigated the lipopolysaccharide (LPS)-induced production of proinflammatory cytokines – interleukin (IL)-1β, IL-6, and TNF-α – in RAW 264.7 murine macrophage cells by quantitative real-time polymerase chain reaction (qRT-PCR) analysis. The sulfur-containing

Enhanced target cell specificity and uptake of lipid nanoparticles using RNA aptamers and peptides

• Roslyn M. Ray,
• Anders Højgaard Hansen,
• Maria Taskova,
• Bernhard Jandl,
• Jonas Hansen,
• Citra Soemardy,
• Kevin V. Morris and
• Kira Astakhova

Beilstein J. Org. Chem. 2021, 17, 891–907, doi:10.3762/bjoc.17.75

• cell types. Histograms are representative of two independent biological experiments, each containing duplicate technical replicates. LNPs do not stimulate secretion of proinflammatory cytokines. A) GMCSF-primed MDMs were treated with LNPs at a ratio of LNPs/cells 1000:1 or with poly I:C or LPS for 24 h

Impact of Pseudomonas aeruginosa quorum sensing signaling molecules on adhesion and inflammatory markers in endothelial cells

• Carmen Curutiu,
• Florin Iordache,
• Veronica Lazar,
• Aurelia Magdalena Pisoschi,
• Aneta Pop,
• Mariana Carmen Chifiriuc and
• Alina Maria Hoban

Beilstein J. Org. Chem. 2018, 14, 2580–2588, doi:10.3762/bjoc.14.235

• proinflammatory cytokines [15] in human lung or fibroblast bronchial cells. 3-Oxo-C12-AHL also activates extracellular signal-regulated kinases (ERKs), which subsequently induces the activation of NFκB transcription factor. Thus, activation of NFκB is essential for maximal IL-8 production following stimulation of

• 2010 that ICAM-1 expression is modulated by ExoU cytotoxin injected via the type III secretion system, being involved in endothelial damage and bacterial dissemination [24]. Inflammatory markers Proinflammatory cytokines and chemokines such as IL-1α, IL-1β, IL-6 and TNFα are produced by vascular cells

Effects of RAMEA-complexed polyunsaturated fatty acids on the response of human dendritic cells to inflammatory signals

• Éva Rajnavölgyi,
• Renáta Laczik,
• Viktor Kun,
• Lajos Szente and
• Éva Fenyvesi

Beilstein J. Org. Chem. 2014, 10, 3152–3160, doi:10.3762/bjoc.10.332

• mediated through the GP120 receptor without interfering with the cell membrane structure. Keywords: cell membrane; cell surface markers; cyclodextrin; enzyme immunoassay; flow cytometry; monocyte-derived dendritic cells; proinflammatory cytokines; RAMEA; solubilization; Introduction The n−3

• the concentration of proinflammatory cytokines were reduced. Both animal experiments and clinical studies confirmed that fish oil supplementation was helpful in rheumatoid arthritis, inflammatory bowel disease, and certain types of asthma [5]. It was concluded that n−3 PUFAs in fish oil exhibit anti